Among the methods devised to address the issue, the two most common (and most often tested) are to pair curcumin with piperine (a black pepper extract) or to combine it with lipids (BCM-95 ®, … In this study, we investigated the effects of administration of gallic acid (Gal) with or without curcumin (Cur) on the sperm output, steroid level and antioxidant defenses in rat testis in vivo and the expression of inflammatory responsive genes in vitro. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. h�b```f``ba`b`��fb@ !�3G��u����0���8�� Learn more. Curcumin is known as an effective antioxidant against oxidative stress. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Histopathology ... number of sperm heads was significantly decreased in the Dex group (< 0.01). The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Extensive studies within the last half a century have demonstrated the protective action of curcumin in many disorders of the body. Mean ± SD of the total sperm count, percent of sperm motility, percent of sperm viability and percent of sperm chromatin dispersion (SCD) of testis in different groups. Please check your email for instructions on resetting your password. The one-way ANOVA showed that the total sperm in the curcumin group had no significant change compared to CFLs and control groups (Figure 2A). Scientific studies have demonstrated the beneficial effects of curcumin on the sperm parameters. Automated semen analysis by SQA Vision® versus the manual approach—A prospective double‐blind study. Effect of curcumin on the total sperm, sperm motility, sperm mortality and testicular weight. Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (HAPNPs), a prospective nano-biomaterial, is extensively studied, its interaction on the reproductive system following exposure is less exploited. Alcohol and water extracts of Curcuma longa show anti-inflammatory effects . Turmeric is a main ingredient of Indian, Persian, and Thai dishes. 41 0 obj <> endobj 47 0 obj <>/Filter/FlateDecode/ID[<73AB0A30A51E44A8904775134F6B434A>]/Index[41 20]/Info 40 0 R/Length 53/Prev 246941/Root 42 0 R/Size 61/Type/XRef/W[1 2 1]>>stream Each point represents the mean of eight experiments. Administration of curcumin significantly reversed sperm viability in the curcumin+sodium arsenite group when compared to the sodium arsenite group (P<0.001). The molecular mechanism(s) by which curcumin affects sperm mo-tility has not been delineated. Cai Zhiming, Reproductive Medicine Centre, the First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital, ShenZhen, China. min along with aflatoxin ameliorated aflatoxin-induced sperm count, immobilization, and viability, and improved the morphologic characteristics of the sperm. This helps increase the sperm count. Conclusion: The current study showed that curcumin could ameliorate the elevated concentration of lipid Male Wistar rats were divided randomly into … Therefore we have hypothesized that sodium arseniteinduced oxidative stress might be responsible for reductions in sperm count. Mexamin-S4 is one such curcumin-rich supplement that is specially created to boost Background: Curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. Conclusion(s): Curcumin has an ameliorative effect on sperm parameters and improves morphologic features of sperm in mice. Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. To minimize error, the count was repeated at least five times for each mouse by two or three coworkers. This study aimed to investigate the effects and specific molecular mechanisms of curcumin on sperm quality in patients diagnosed with leucocytospermia. After curcumin treatment, the level of the H2O2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. Diarylheptanoids as nutraceutical: A review. Converging evidence from animal and human studies. levels of follicle stimulating hormone, prolactin, testicular weight, sperm motility, TDI, and SPI. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen … ELISA was used to measure the changes in H2O2, sperm mitochondrial DNA (mtDNA), cytochrome B (Cyt B) and NADH dehydrogenase 5 (NADH5) contents before and after curcumin treatment. The impact of curcumin on resisting mercuric chloride toxicity is dose dependent and was statistically significant. with AO showed that addition of curcumin had a significant effect on the sperm DNA integrity compared to that of the control group (Fig. ��,L��� �0gi��,@{��. Curcumin as an atoxic antioxidant can reduce production of NO. and you may need to create a new Wiley Online Library account. hޔV�n�8��@��{&ͤ ���d/�5!���R7ӯ_R�=N�t��uxH��8Y��%〥�KCE)K#4� As shown in figure 2A, treat rats with CFLs in the CFLs group total sperm count compared to the control group. Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction. Objective: This study evaluated the protective effect of curcumin on … Curcumin also has a protective effect against the harmful impact of DEHP on the male reproductive system. The molecular mechanism(s) by which curcumin affects sperm motility has not been delineated. … 4A–D). (Fertil Steril 2008;90:775–80. This study aimed to investigate the ef … Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). 2 and Table 1). Effect of curcumin on chromium-induced oxidative ... reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities ... ity, sperm abnormalities leading to infertility (Bonde, 1993). Effect of curcumin on dexamethasone-induced testicular toxicity in mice ... averaged. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Click here to view When low‐dose curcumin (10 mg/kg) was administered to diabetic rats, we found that curcumin significantly increased sperm motility and density, and decreased abnormal … The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Each point represents the mean of eight experiments. Figure 1: The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. Altered testicular histology, reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities were observed following K(2)Cr(2)O(7) exposure while curcumin supplementation along with K(2)Cr(2)O(7) exposure had shown to prevent the altered parameters. In conclusion, curcumin can significantly improve sperm motility of leucocytospermic patients, against the oxidative damage induced by H2O2. The Effect of Adding Different Levels of Curcumin and Its Nanoparticles to Extender on Post-Thaw Quality of Cryopreserved Rabbit Sperm. (*P < 0.05, **P < 0.01 and ***P < 0.001). The effect of curcumin-loaded iron particles on sperm parameters in long term scrotal hyperthermia induced mice. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Our results also showed that curcumin supplementation following CFLs reversed these alterations. Antioxidants modulation of sperm genome and epigenome damage: Fact or fad? �fbV��$~a��"�R,Z�@��/ >� endstream endobj 42 0 obj <> endobj 43 0 obj <> endobj 44 0 obj <>stream Computer‐assisted semen analysis (CASA) was used to detect sperm motility after curcumin incubation. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. This work was supported by grants from the National Natural Science Foundation of China (Grant Number 81401258), Guangdong Natural Science Foundation (Grant Number 2014A030313652), Shenzhen Foundation of Science and Technology (Grant Number JCYJ20140414170821307 and JCYJ20150330102401083), Medical Scientific Research Foundation of Guangdong (Grant Number A2015122). Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Curcumin is known as an effective antioxidant against oxidative stress. After curcumin treatment, the level of the H2 O2 was significantly decreased in the supernatant of curcumin-incubated spermatozoa from leucocytospermic patients. %PDF-1.6 %���� This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. Forty cases of semen samples were collected from patients with leucocytospermia and 35 cases from normal fertile male. Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm … If you do not receive an email within 10 minutes, your email address may not be registered, Emails: hxzl48@163.com; caizhiming2000@163.com. Context: Curcumin is a yellow-orange polyphenol derived from turmeric [Curcuma longa L. (Zingiberaceaerhizomes)]. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species. FINDINGS: Mean sperm count in control group was (4.17±0.84) while it reduced after reception of 300 mg/kg D-galactose (3.06±0.86). What does this mean? Use the link below to share a full-text version of this article with your friends and colleagues. Mexamin S4 gradually yet significantly help deal with the sperm count and mobility concerns. Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation. Curcumin is known as an effective antioxidant against oxidative stress. There was a significant increase in the sperm parameters in Curcumin group compared to the D-galactose group (p<0.05). Biocatalysis and Agricultural Biotechnology. It increases the level of antioxidant enzyme and supports spermatogenesis. After curcumin treatment, the level of the H 2 O 2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. The content of mtDNA was significantly decreased, while the content of Cyt B and NADH5 in spermatozoa was significantly increased. Furthermore, CFLs had no effect on serum levels of luteinizing hormone and sperm count and also, increased abnormal sperm shapes. Motile sperm count, LH, FSH and progesterone level decreased in mercuric chloride exposed groups and was statistically significant (Table 3, Fig. Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conduct-ed to investigate the effect of curcumin on these sperm (human and murine) parame-ters. By itself, curcumin is poorly absorbed. Since curcumin is a potent antioxidant , it can reverse the adverse effects of sodium arsenite on sperm count. N = 6 rat per group. Working off-campus? Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti‐inflammatory effects. The aim of this study was to determine the effect of curcumin on NO levels and investigate if curcumin can improve sperm parameters in var icocelized male rats. The antimicrobial and anti-inflammatory properties of Curcumin keep any type of infection and swelling at bay. Curcumin has a very strong antioxidant effects at applied doses and it can probably be used as an antioxidant and food supplement in reproductive disorders.Journal of Medical and Biomedical Sciences (2017) 6(2), 1-10 Learn about our remote access options, Clinical College of Shenzhen Second Hospital Affiliated AnHui Medical University, ShenZhen, China, Department of Integrated Chinese Medicine and Western Medicine, First Hospital Affiliated ShenZhen University, ShenZhen, China, Reproductive Medicine Centre, The First Affiliated Hospital of ShenZhen University, ShenZhen No.2 Hospital, ShenZhen, China. Prospects for the Use of Indole-3-carbinol in the Treatment of Benign Prostatic Hyperplasia. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Curcumin is known as an effective antioxidant against oxidative stress. The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). h�bbd``b`��@�q�`��\@b�~&F� YF2���3� E�� endstream endobj startxref 0 %%EOF 60 0 obj <>stream The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Therefore, curcumin may play a role in mitigating the H2O2‐induced injury to sperm. BACKGROUND: Type one diabetes mellitus (DM) is a multisystem disorder whose effects are observed in the reproductive system.Considering the role of curcumin in lowering blood glucose and enhancing antioxidant defense, this research aimed to determine protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in diabetic rats. Sperm Total antioxidant capacity (TAC). Curcumin’s antioxidant and anti-inflammatory activity ameliorates the damage caused by reduced blood flow occurring due to torsion. Number of times cited according to CrossRef: Environmental Impact on Male (In)Fertility via Epigenetic Route. A significant increase was observed in the level of thiol and superoxide dismutase enzyme This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. However, the application of curcumin alone had no significant effect on sperm viability compared to the … Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. In the present study, male rats were exposed to HAPNPs (300 mg/kg BW) to determine its possible reproductive toxicity. For each mouse by two or three coworkers by reactive oxygen species significant increase in Dex. 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